Study on the Toxicity of Plasticizer

There are a wide variety of plasticizers, and various plasticizer toxicity data vary widely. In comparison, chlorinated hydrocarbon plasticizers (chlorinated paraffins) are more toxic due to the presence of photographic substances (fluorescent substances), and citric acid esters , Epoxy soybean oil (ESO) plasticizer is considered non-toxic plasticizer.

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Common phthalates (also known as phthalate esters), DEHP toxicity coefficient T = 200, rats and rabbits oral LD50 greater than 3000mg / kg body weight, so low toxic substances. The French Cancer Institute, which contains four generations of rats containing 0.05% of the feed, showed no teratogenicity and carcinogenicity. The United States Department of Environmental Sciences, Institute of Scientific Research with greater doses of DEHP-fed male mice and male rats with vas deferens degeneration, forelimb pituitary cell hypertrophy. Monkeys (marmosets) in the repeated treatment of DEHP containing plasma, liver tissue lesions.

Other common phthalate plasticizer toxicity: DBP (dibutyl phthalate) toxicity coefficient T = 50, the animals (rats, rabbits, dogs) oral LD50 greater than 8000mg / kg body weight , So it is non-toxic. 100mg / kg body weight of the rats fed five generations, 300mg / kg body weight and 500mg / kg body weight of the rats fed three generations, the animal's reproductive, growth curve, histological examination are any abnormalities, and no carcinogenicity The Studies have reported that exposure of rodents to DBP can cause testicular atrophy, or decreased fertility; another study reported that DBP has anti-cancer effect.

DBP in the anti-cancer study has a new pharmacological function, mice intraperitoneal injection of S180 cells without injection of DBP, 38 days after the emergence of ascites tumors in mice all died. However, mice with DBP-labeled S180 cells had prolonged survival time, and 33.3% of the mice were normal within 3 months. Bone marrow suspension in horse serum and rat lungs in the culture medium by adding DBP, leukemia cells were significantly reduced, and rapid degradation. It is very effective to purify residual cancer cells on their own bone marrow. But other phthalate plasticizer is no such function.