• Home
  • NEWS > > The basic situation of plasticizers

The basic situation of plasticizers

There are various types of plasticizers, and the data on the toxicity of various plasticizers vary greatly. In comparison, chlorinated hydrocarbon plasticizers (chlorinated paraffins) are highly toxic due to the presence of photosensitive substances (fluorescent substances) and citric acid esters. Epoxy soybean oil (ESO) plasticizers are considered non-toxic plasticizers.

Common phthalates (also called phthalates), DEHP toxicity factor T = 200, rats and rabbits oral LD50 greater than 3000mg/kg body weight, it is a low toxic substance. The French Cancer Institute fed four generations of rats with feed containing 0.05% of the product. The results showed no teratogenicity and carcinogenicity. The Department of Health Sciences of the U.S. Department of Health Sciences degenerated the vas deferens in male mice and male rats fed with larger doses of DEHP, and the somatic hypertrophy of the forelimbs. Monkeys (狨) suffered from lesions in liver tissue after receiving multiple plasmas containing DEHP.

The toxicity of other common phthalate ester plasticizers: DBP (dibutyl phthalate) toxicity factor T=50, oral LD50 for animals (rats, rabbits, dogs) greater than 8000 mg/kg body weight Therefore, it is non-toxic substance. The rats were fed 100 mg/kg body weight for five generations of rats, 300 mg/kg body weight and 500 mg/kg body weight were fed to the third generation of rats. The animals' reproduction, growth curve, and histological examination were all abnormal and no carcinogenicity. . According to a research report, exposing rodents to DBP can cause testicular atrophy or decreased fecundity; another research report claims that DBP has anti-cancer effects. DBP has new pharmacological functions in anti-cancer research. When mice injected S180 cells without intraperitoneal injection of DBP, all mice died of ascites tumors after 38 days. However, the survival time of mice injected with DBP S180 cells was prolonged, and 33.3% of mice were normal within 3 months. Bone marrow suspension, when DBP was added to the culture medium of horse serum and rat lung, significantly reduced leukemia cells and rapidly degraded. It is very effective in transplanting bone marrow itself and purifying residual cancer cells. However, other phthalate plasticizers do not have this function.

expert's point

According to Liu Zhaoping, a researcher at the Institute of Nutrition and Food Safety at the Chinese Center for Disease Control and Prevention, plasticizers, as an environmental hormone, are widespread in every aspect of daily life, and plasticizers exist in air, soil, and water. Trace plasticizers have no significant effect on human health.

x

By clicking "Allow All", you agree to the storage of cookies on your device to enhance site navigation, analyze site usage and assist with our marketing efforts. Cookie Notice